There are certain things that restrict the realization our potentials. The most harm is done when the restriction is imposed on each of us as a system of implicit and often unfathomable constraints.
Although the phenomenon is quite universal, we can start from specific examples. The social enclosure of challenged people, for example.
Recently, I had a chance to converse with a few people who are without vision by birth or through medical conditions, as part of a research for a book project. I found, or should I say rediscovered, that the brains of the visually challenged people are used in a different manner from us. As a consequence, they have developed a unique set of abilities which are a marvel for those "cursed" with visual abilities.
As an instance, when we move around the city, we rely on the visual information so much that our navigation is executed relying on the incessant sensori-motor interaction supported by vision. So when questioned out of location, one has only a very fuzzy idea of the nature of the actual route taken. A blind person, on the other hand, plans and remembers the journey in a very explicit and rule based way, so that they have in mind a vivid description of almost algorithmic rigor as regards how to move around.
Thus, one finds a more logically robust and dense set of abilities in a visually challenged person. There are accompanying difficulties naturally, but if we can find a way to overcome these obstacles, a visually challenged person has a great chance of flourishing in a unique way. Sadly, because of the assumptions and prejudices about what one may do in society, these great capabilities are not tapped to the full yet.
Similar cases of untapped talent resources are rampant in society. Glass ceilings are broken constantly as society progresses.
The real problem is that in many cases we don't even realize the existence of the glass ceiling, and suffocate without knowing the reason why.